Aging results from the progressive depletion of stem cells, so the introduction of new stem cells has the potential of slowing down or reversing this process."Stem cell therapies are among the world's greatest collective scientific breakthrough, possessing the clear potential to revolutionize the practice of medicine and improve the quality and length of life." Townsend Letter for Doctors and Patients.
Stem cells possess a unique anti-aging effect by improving immune function and regenerating and repairing organs damaged by stressors, like free radicals and the various toxins we are exposed to in our day to day living.
Your body uses its own stem cells to make you stronger, healthier and more resistant to disease. As we age, we use stem cells to repair damaged organs, or to replace those stem cells destroyed by toxins over time.At all stages of your life, your body fights damage by using stem cells. When you smoke, stem cells head for the lungs. When you are sun burnt, they repair the skin. As late as the early 2000's, we did not know that stem cell replenishment was true for most organs, but today we know that every organ seems to recruit stem cells from the bone marrow to resuscitate itself.
Decline in stem cell production with age As we age, however, the bone marrow releases fewer stem cells, giving us less power to repair the damage of ageing. Treatment with adult stem cells reverses this process.In healthy individuals, skin youthfulness is maintained by epidermal stem cells which self-renew and generate daughter cells that become new skin. Despite accumulation of aging blemishes and changes in aged skin, epidermal stem cells are maintained at normal levels throughout life. Therefore, skin ageing is caused by impaired stem cell mobilization from the bone marrow or reduced number of stem cells able to respond to repair signals. (6). This means that, if we increase the number of circulating stem cells, by mobilizing from the bone marrow, and by infusion of additional stem cells we should dramatically change this cell behavior.
It has been postulated that stem cell exhaustion from the bone marrow is partly responsible for the process of cardiovascular ageing and the resulting diseases such as angina, heart attack, stroke and senile dementia. It has now been proven that stem cell damage in the bone marrow, from aging, is responsible for coronary artery disease and resultant cardiac muscle damage. (1, 2, 4). This means that cardiac disease can be prevented by stem cell therapy.
As aging progresses, there is a decline in the brain's capacity to produce new neurons. The underlying cause of the declining neurogenesis is unknown, but is presumably related to age-related changes that occur during normal aging of the brain. It is exacerbated by age-related neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. (5).
References: 1. Spyridopoulos I et al. Arteriosclerosis, Thrombosis & Vascular Biology. 28(5):968-974, May 2008. 2. José J. Fuster, Vicente Andrés.Circulation Research. 2006;99:1167.2006 American Heart Association, Inc.Reviews.Telomere Biology and Cardiovascular Disease. 3. Ignacio Flores, Roberta Benetti and Maria A Blasco. Telomerase regulation and stem cell behaviour. Current Opinion in Cell Biology 2006, 18:254–260. 4. Frederick M. Rauscher et al.Aging, Progenitor Cell Exhaustion, and Atherosclerosis. Circulation, The American Heart Association. 5. TL Limke, MS Rao, Neural stem cell therapy in the aging brain: pitfalls and possibilities. J Hematother Stem Cell Res (2003) 12: 615-23. 6. Zouboulis CC, Adjaye J, Akamatsu H, Moe-Behrens G, Niemann C.Human skin stem cells and the ageing process. Exp Gerontol. 2008 Sep 9.
According to the American Academy of Anti-aging Medicine, stem cells appear to be our most powerful tool in Regenerative Medicine at this time. Previous dogma concerning adult stem cells taught that our tissues did not have stem cells and the cells present at birth just declined in quantity and quality until there was nothing left. It was also believed that hematopoietic stem cells lacked plasticity and could not transform to other tissues.Current medical literature proves that adult stem cells exist in most tissues including brain, heart, muscles and liver and adult stem cells have plasticity to potentially transform and repair all tissues and organs.Current literature also shows that stem cell supplementation of an age-damaged bone marrow stem cell population can result in rejuvenation and the increase in longevity of that stem cell source. (1 )
Reference: 1. Ignacio Flores, Roberta Benetti and Maria A Blasco. Telomerase regulation and stem cell behaviour. Current Opinion in Cell Biology 2006, 18:254–260.
Osteoarthritis responds well to joint infusions of stem cells as shown in phase III trials in the USA. Early Alzheimer’s disease can be reversed and Parkinson’s disease has shown excellent improvement when treated in the early stages. Emotional and cognitive improvement occurs, which you will notice as your memory improves, concentration ability increases and your ability to handle complex tasks, as you did before, is regained. An increase in energy levels and a resistance to disease develops as your cardiovascular, nervous and immune systems are boosted by the stem cell infusion. You will find that you will have higher levels of energy than before.
The most evident beauty response in stem cell treated patients is the appearance of the facial skin a few weeks after therapy - it glows. You will notice a smoothness and improvement in color along with a look of youthfulness.Grey hair has been noted to regain its original color and bald spots have filled in. The rest of your skin will show an improvement in color and age-related pigmentation marks, less bruising and an increase in elasticity and tone.
You can expect improvements after stem cell therapy, including but not limited to:
1. Physical improvements such as:
• Less head/neck aches• Decreased soreness in neck, arms and legs• Reduced stiffness in joints• Far less tiredness or fatigue
2. Aesthetic improvements such as:
• The skin on the face and hands becomes tighter• Fewer wrinkles• Looking younger - general younger appearance• Change in color of hair from grey to black/normal• Hair thickens
3. Mental and Emotional improvements.
4. Improvements in Energy Levels.
5. Improvement in the Overall Quality of Life.
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