Mesenchymal Stem Cells (MSCs)
Mesenchymal stem cells are multipotent stem cells derived from various adult and fetal tissues that are capable of supporting hematopoiesis and differentiating into multiple lineages (osteogenic, adipogenic, chondrogenic, neurogenic, myogenic, and cardiomyogenic.)
Features of MSCs
Mesenchymal stem cells (MSCs) are advantageous over other stem cells types for a variety of reasons. First, they avoid the ethical issues that surround embryonic stem cell research.
Second, repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogeneic transplantation. MSCs reduce both the risks of rejection and complications of transplantation.
Third, there have been advances in the use of umbilical cord mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, and bone fractures, because MSCs can exert regenerative effects through homing to sites of damage, paracrine signalling, regulating immune responses, and positively affecting the microenvironment.
Keeping Mesenchymal Stem Cells Young
During culture, MSCs are expanded in numbers to reach therapeutically beneficial numbers. However, every time a stem cell divides (self-renews) it loses some of its abilities. In a way each time a cell divides it ages, becoming slower and less able to perform its specialist tasks. At StemCells21 we produce 2 grades of UCMSCs – Premium: Passage 1 Mesenchymal Stem Cells (P1 MSCs) (with higher rates of efficiency) and 3 Mesenchymal Stem Cells (P3 MSCs).