Mesenchymal Stem Cells

Mesenchymal Stem Cells (MSCs)

Mesenchymal stem cells are early passage multipotent progenitor cells derived from human cord tissue that are capable of supporting hematopoiesis and differentiating into multiple lineages (osteogenic, adipogenic, chondrogenic, neurogenic, myogenic, and cardiomyogenic.)

Why Use MSCs

Mesenchymal stem cells (MSCs) are advantageous over other stem cells types for a variety of reasons. First, they avoid the ethical issues that surround embryonic stem cell research.

Second, repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogeneic transplantation. MSCs reduce both the risks of rejection and complications of transplantation.

Third, there have been advances in the use of umbilical cord mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, and bone fractures, because MSCs can exert regenerative effects through homing to sites of damage, paracrine signalling, regulating immune responses, and positively affecting the microenvironment.

MSC Culture Images

MSCs in Culture: Day 13

MSCs in Culture: Day 22

MSCs in Culture: Day 28

Keeping Mesenchymal Stem Cells Young

During culture, MSCs are expanded in numbers to reach therapeutically beneficial numbers. However, every time a stem cell divides (self-renews) it loses some of its abilities. In a way each time a cell divides it ages, becoming slower and less able to perform its specialist tasks. At StemCells21 we produce 2 grades of UCMSCs – Premium: Passage 1 Mesenchymal Stem Cells (P1 MSCs) (with higher rates of efficiency) and 3 Mesenchymal Stem Cells (P3 MSCs).

Mechanism’s for Functional Deterioration of Stem Cells in Aging:


MSCs avoid the ethical issues of embryonic stem cells, as they can be derived from sources that include adult bone marrow and adipose tissue.

Diverse Differentiation Potential:

MSCs can form a variety of cell types in the laboratory, including those of both intra– and extra-mesenchymal lineage. These cell types include fat (adipocytes), bone (osteoblasts), skin (dermal cells), nerve (neural cells), cartilage (chondrocytes), muscle (skeletal myocytes), tendons (tenocytes), marrow stroma, ligaments, and more.

Ease of Growth in Culture:

Advanced knowledge exists for how to grow MSCs in culture, including protocols for isolation, expansion, and differentiation.

Flexible Propagation:

MSCs can be grown and propagated in culture for extended periods, without losing differentiation potential.

Role as Regulatory Cells:

MSCs synthesize and secrete a variety of macromolecules that are known regulators of hematopoietic and other regenerative cells.

Favorable Immune Status:

MSCs lack the co-stimulatory molecules of the B7 family that is required to initiate an immune response. This allows the administration of MSC preparations across MHC barriers without concern for immunological rejection or the need for immunosuppression, making Mesenchymal stem cells a universal stem cells source.