Cerebral Palsy Stem Cell Treatment

Cerebral Palsy Stem Cell Treatment: Described as a non-progressive motor disability, cerebral palsy (CP) occurs due to abnormal development or damage occurring to the developing brain. Cerebral Palsy treatment is available at our medical facility in  Bangkok, Thailand.

Cerebral Palsy Stem Cell Therapy

Commonly referred to as CP, cerebral palsy affects the normal movement of different parts of the body and has several degrees of severity. The term “cerebral” speaks of the brain’s cerebrum, a part of the brain that controls motor functions whereas “palsy” refers to paralysis of voluntary movement in specific body parts.

The cerebrum in the brain regulates all types of motor functions that allow you to live independently. Motor functions can be either voluntary or involuntary. When the cerebrum is injured, both voluntary and involuntary fail to function properly hence presenting a range of challenges related to walking, talking or even handling simple everyday tasks independently.
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CP is caused by deformity or interruption in the brain development, normally before the child is delivered. In most cases, the exact cause remains unknown but factors that deter brain development include:
  • Maternal infection; German measles, chicken pox, herpes toxoplasmosis or any other viral ailment of the mother in early pregnancy
  • Gene’s mutations
  • Fetal stroke
  • Infant infection that leads to inflammation in/around the brain
  • Prolonged loss of oxygen (asphyxia) during the perinatal period or delivery process
  • Birth injury caused by medical negligence

Stem Cell Treatment for Cerebral Palsy

Mesenchymal Stem Cells (MSCs) are one of the most studied types of stem cells for cerebral palsy treatment. The potential of MSCs:

Mesenchymal Stem Cell Treatment Mode of Action and Therapeutic Benefit for Cerebral Palsy Stem Cell Therapy

Umbilical cord mesenchymal stem cell (UC-MSC) therapy has shown potential as a therapeutic approach for individuals with cerebral palsy (CP). Here are some of the  modes of action and potential therapeutic benefits seen from cerebral palsy stem cell treatment:

Mode of Action:

  1. Neuroprotection and Neuroregeneration: UC-MSCs have the ability to secrete various growth factors, cytokines, and chemokines that support neuroprotection and neuroregeneration. They can promote the survival of existing neurons, stimulate the growth of new neurons, and enhance the formation of neural connections in the damaged areas of the brain.

  2. Immunomodulation: UC-MSCs possess immunomodulatory properties, and they can modulate the immune response and reduce inflammation. In CP, inflammation can contribute to further brain injury and impair neurological function. By modulating the immune response, UC-MSCs may help reduce inflammation and create a more favorable environment for brain repair and functional recovery.

  3. Trophic Support: UC-MSCs release various trophic factors, including brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), and nerve growth factor (NGF). These factors can support the survival and growth of neurons, enhance neuronal function, and promote neuroplasticity.

Therapeutic Benefits:

  1. Motor Function Improvement: UC-MSC therapy has shown promise in improving motor function in individuals with CP. This can include enhancements in muscle strength, coordination, balance, and gross and fine motor skills. Improved motor function can lead to increased independence and quality of life.

  2. Reduction of Spasticity: Spasticity, a common symptom in CP, involves increased muscle tone and stiffness. UC-MSC therapy has been reported to help reduce spasticity, allowing for better mobility and ease of movement.

  3. Cognitive and Developmental Improvements: Some studies suggest that UC-MSC therapy may have positive effects on cognitive function and developmental outcomes in individuals with CP. This can include improvements in attention, memory, learning, and overall cognitive abilities.

  4. Functional Independence: UC-MSC therapy has the potential to enhance functional independence by improving activities of daily living (ADLs), such as self-care, mobility, and communication skills. 

Beneficial Actions of Stem Cells for CP

  • Cross the endothelial brain barrier
  • Migrate to sites of injury (chemotaxis)
  • Communicate with and alter nearby cells (paracrine effect) 
  • Encourage existing cells to self-repair (autocrine effect)
  • Immune modulation
  • Transform into neurons and glia 
  • Promote the formation of nerve cell axons (axogenesis) 
  • Release neuroprotective factors 
  • Encourage existing cells to adapt (neuroplasticity)

Results Achieved with Stem Cell Treatment CP:

  • Regained motor development and coordination
  • Regained eyesight
  • Improved mental retardation
  • Increased muscle strength
  • A decrease in spasticity and improved muscle tone in hypotonic patients
  • Improvement in balance and coordination, and gross motor skills