Stem Cells During The Aging Process
During the aging process, our stem cell numbers decline, and functionality of the stem cells reduces. This decline is increased with disease and injury as more stem cells are forced into use.
Stem Cells: As We Age
There is increasing evidence that the aging process can have adverse effects on stem cells. As stem cells age, their renewal ability deteriorates and their ability to differentiate into the various cell types is altered. Accordingly, it is suggested aging-induced deterioration of stem cell functions may play a key role in the pathophysiology of the various aging-associated disorders.
Understanding the role of the aging process in deterioration of stem cell function is crucial, not only in understanding the pathophysiology of aging-associated disorders but also in the future development of effective stem cell-based therapies to treat aging-associated diseases.
Adult stem cells, also known as somatic stem cells, are found throughout the body in every tissues and organ after development and function as self-renewing cell pools to replenish dying cells and regenerate damaged tissues throughout life.
However, adult stem cells appear to age with the person. As stem cells age, their functional ability also deteriorates. Specifically, this regenerative power appears to decline with age, as injuries in older individuals heal more slowly than in childhood. For example, healing of a fractured bone takes much longer time in elderly than in young individuals.
There is a substantial amount of evidence showing that the deterioration of adult stem cells in the adult phase can become an important player in the initiation of several diseases in aging.
Treatable Conditions with P1 MSCs
At StemCells21 we create stem cells that are used to treat a wide range of chronic diseases and for rejuvenating affects for ageing.
We believe keeping the mesenchymal stem cells juvenile and functioning in a youthful manner, will deliver the most beneficial regenerative medicine treatment.